PhD Position in ecotoxicology and evolution
A PhD position is available on the adaptive potential of molecular
responses to stress, of a freshwater snail exposed to pesticides.
Position is opened in the group of Ecotoxicology and quality of aquatic
environments, UMR ESE 985, Rennes, of the French National Institute for
Agricultural Research (INRA).
The project is proposed in the context of population ecological risk
assessment and pesticide use. Evolutionary processes are only recently
incorporated as a relevant dimension into these research issues. Such
processes are difficult to predict, due to the diversity of their
potential determinants, among which: (i) activated mechanisms of
physiological and molecular defence, (ii) interactions, (iii)
relationship with other traits, including those related to fitness, (iv)
potential cost, (v) population characteristics, including history of
exposure, population size and level of genetic variability.
Specific issues addressed in this project relate to the components of
variation observed at the level of biochemical and molecular systems
activated in response to pesticide stress, in a freshwater snail,
/Lymnaea stagnalis/. We are specifically interested in estimating the
adaptive potential of such systems (enzymatic activity, expression of
genes involved in the antioxidant pathway and in less specific stress)*.
The amount of genetic additive variation will be estimated using
quantitative genetics (experimental lines), and adaptive divergence
between populations will be searched for by comparing contrasted
ecotypes, using common-garden experiments. Fitness-related traits will
be jointly measured, in order to estimate possible costs and trade-offs.
*depending on fundings obtained, the project may be extended to gene
expression at a larger scale (transcriptomics)./
Salary: the project is currently submitted to several national /
regional grant sources, including INRA’s “Young Researcher Contract”,
which includes both a 3 year PhD funding and a 2 year postdoc funding.
(before June 1^st ): CV, documentation of undergraduate grades, names
and addresses of two referees and a statement describing the reason(s)
for your interest in this research to:
marie-agnes.coutellec[at]rennes.inra.fr
See also “sujet n°89” at:
http://www.vas.univ-rennes1.fr/themes/Concours_annuel/Profils/Autres/
Marie-Agnès Coutellec
UMR INRA-Agrocampus Ouest 985 ESE
Equipe Ecotoxicologie et Qualité des Milieux Aquatiques
65 rue de Saint-Brieuc - CS 84215
35042 Rennes cedex - FRANCE
tél.: +33(0)2 23 48 52 48
fax: +33(0)2 23 48 54 40
marie-agnes.coutellec[at]rennes.inra.fr
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